SADR Gengle™ - a Database Inheriting Google® Technology in Presenting Genes Responsible for Serious Adverse Drug Reactions

CitationRank Algorithm

Sorting SADR related genes by their CRR value potentially creates false negatives. For example, it would be wrong to assign a low importance to a gene because currently its citation rate is low, since our knowledge of the molecular mechanism of SADRs is limited, especially when the gene is biologically linked to other genes with high CRRs, it remains unclear, therefore, whether this gene should be omitted. This problem is particularly acute in SADR research, where knowledge of all SADR related genes is scarce anyway. Following the logic of the Google PageRank algorithm, we put forward an algorithm named CitationRank...

 

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Serious adverse drug reaction (SADR) is an urgent, world-wide problem. As no gene-oriented SADR knowledge has been well organized, we constructed the first gene-oriented SADR database named SADR Gengle™ for six major SADRs, which is made up of gene-SADR relationships extracted from Pubmed.

Since the importance of a gene to a particular SADR cannot simply be defined in terms how frequently the two are cited together in the literature, an algorithm named CitationRank, which has been realized on a genes' knowledge chain network (GKCN), is devised to sort genes according to their relevance to the SADR topics.

Knowledge Chain Network

A bibliomic Network

Since human knowledge on SADR related genes is scattered and is not well organized, the database provides users with visualized GKCN, helping them to systematize their gene-oriented knowledge chain whilst navigating this network.

Basic principle of constructing the GKCN: If two genes are co-cited in an entry, they tend to relate to each other biologically directly or indirectly. A connection between two genes is therefore established if they are co-cited in at least two Pubmed entries.

Topics

Muscle Toxicity Torsades de Points
Deafness QT Prolongation
Cholestasis Stevens-Johnson Syndrome
 
Subscribe updating of the topics here.
Deafness Muscle Toxicity Cholestasis QT Prolongation Stevens-Johnson Syndrome Torsades de Points