SADR Gengle™ - a Database Inheriting Google® Technology in Presenting Genes Responsible for Serious Adverse Drug Reactions

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Deafness



Pathway Foreground Gene Count & Ratio Background Gene Count & Ratio p-value q-value
Focal adhesion 80 / 11.46% 199 / 2.48% 1.89E-25 3.10E-23
Prostate cancer 55 / 7.88% 90 / 1.12% 2.79E-24 2.29E-22
Small cell lung cancer 49 / 7.02% 85 / 1.06% 6.25E-21 3.42E-19
Chronic myeloid leukemia 43 / 6.16% 72 / 0.90% 6.20E-19 2.54E-17
MAPK signaling pathway 80 / 11.46% 277 / 3.45% 3.99E-18 1.31E-16
Pancreatic cancer 40 / 5.73% 69 / 0.86% 2.33E-17 6.37E-16
p53 signaling pathway 38 / 5.44% 65 / 0.81% 1.22E-16 2.85E-15
Colorectal cancer 42 / 6.02% 86 / 1.07% 3.98E-16 8.17E-15
Apoptosis 42 / 6.02% 88 / 1.10% 7.48E-16 1.36E-14
Melanoma 38 / 5.44% 71 / 0.88% 1.08E-15 1.77E-14
Non-small cell lung cancer 33 / 4.73% 53 / 0.66% 3.34E-15 4.90E-14
Toll-like receptor signaling pathway 44 / 6.30% 103 / 1.28% 3.59E-15 4.90E-14
Glioma 35 / 5.01% 64 / 0.80% 9.14E-15 1.15E-13
Bladder cancer 28 / 4.01% 40 / 0.50% 5.21E-14 6.10E-13
T cell receptor signaling pathway 39 / 5.59% 89 / 1.11% 7.25E-14 7.82E-13
Natural killer cell mediated cytotoxicity 49 / 7.02% 142 / 1.77% 7.63E-14 7.82E-13
Protein kinases 96 / 13.75% 463 / 5.76% 1.48E-13 1.42E-12
Endometrial cancer 29 / 4.15% 51 / 0.63% 8.97E-13 8.17E-12
Cytokine-cytokine receptor interaction 67 / 9.60% 275 / 3.42% 2.37E-12 2.04E-11
Acute myeloid leukemia 29 / 4.15% 54 / 0.67% 2.64E-12 2.16E-11
ErbB signaling pathway 35 / 5.01% 84 / 1.05% 4.46E-12 3.48E-11
Jak-STAT signaling pathway 28 / 4.01% 56 / 0.70% 2.32E-11 1.73E-10
Cell cycle 39 / 5.59% 115 / 1.43% 4.41E-11 3.14E-10
Cellular antigens 90 / 12.89% 480 / 5.98% 1.13E-10 7.70E-10
Type I diabetes mellitus 24 / 3.44% 44 / 0.55% 1.62E-10 1.07E-09
Adipocytokine signaling pathway 29 / 4.15% 68 / 0.85% 2.03E-10 1.28E-09
Fc epsilon RI signaling pathway 29 / 4.15% 70 / 0.87% 3.49E-10 2.12E-09
Renal cell carcinoma 28 / 4.01% 67 / 0.83% 6.03E-10 3.53E-09
B cell receptor signaling pathway 28 / 4.01% 69 / 0.86% 1.03E-09 5.80E-09
ECM-receptor interaction 30 / 4.30% 84 / 1.05% 2.99E-09 1.63E-08
CAM ligands 41 / 5.87% 152 / 1.89% 4.43E-09 2.34E-08
VEGF signaling pathway 26 / 3.72% 67 / 0.83% 8.60E-09 4.41E-08
Regulation of actin cytoskeleton 49 / 7.02% 213 / 2.65% 1.22E-08 6.04E-08
Cytokines 51 / 7.31% 229 / 2.85% 1.52E-08 7.35E-08
Epithelial cell signaling in Helicobacter pylori infection 25 / 3.58% 65 / 0.81% 1.92E-08 9.00E-08
Adherens junction 26 / 3.72% 72 / 0.90% 2.84E-08 1.29E-07
Leukocyte transendothelial migration 31 / 4.44% 113 / 1.41% 2.55E-07 1.13E-06
Thyroid Cancer 15 / 2.15% 29 / 0.36% 7.69E-07 3.32E-06
Gap junction 27 / 3.87% 98 / 1.22% 1.41E-06 5.95E-06
Antigen processing and presentation 25 / 3.58% 88 / 1.10% 2.18E-06 8.95E-06
Progesterone-mediated oocyte maturation 27 / 3.87% 103 / 1.28% 3.15E-06 1.26E-05
Insulin signaling pathway 31 / 4.44% 132 / 1.64% 4.25E-06 1.66E-05
TGF-beta signaling pathway 24 / 3.44% 87 / 1.08% 5.32E-06 2.03E-05
Type II diabetes mellitus 16 / 2.29% 41 / 0.51% 6.06E-06 2.26E-05
Huntington's disease 13 / 1.86% 29 / 0.36% 1.41E-05 5.14E-05
Melanogenesis 24 / 3.44% 101 / 1.26% 4.34E-05 1.55E-04
Complement and coagulation cascades 19 / 2.72% 69 / 0.86% 5.13E-05 1.79E-04
Metabolism of xenobiotics by cytochrome P450 19 / 2.72% 70 / 0.87% 6.05E-05 2.07E-04
Cell adhesion molecules (CAMs) 42 / 6.02% 242 / 3.01% 6.59E-05 2.21E-04
mTOR signaling pathway 15 / 2.15% 48 / 0.60% 9.72E-05 3.19E-04
Dorso-ventral axis formation 10 / 1.43% 24 / 0.30% 2.24E-04 7.20E-04
GnRH signaling pathway 21 / 3.01% 94 / 1.17% 2.68E-04 8.44E-04
Ubiquitin mediated proteolysis 25 / 3.58% 125 / 1.56% 3.22E-04 9.96E-04
Wnt signaling pathway 27 / 3.87% 149 / 1.86% 7.32E-04 2.22E-03
Long-term depression 17 / 2.44% 76 / 0.95% 9.89E-04 2.95E-03
Glutathione metabolism 11 / 1.58% 39 / 0.49% 1.64E-03 4.81E-03
Hematopoietic cell lineage 17 / 2.44% 81 / 1.01% 1.80E-03 5.18E-03
Long-term potentiation 15 / 2.15% 69 / 0.86% 2.44E-03 6.91E-03
Amyotrophic lateral sclerosis (ALS) 6 / 0.86% 15 / 0.19% 4.89E-03 1.36E-02
One carbon pool by folate 6 / 0.86% 16 / 0.20% 6.28E-03 1.72E-02
Axon guidance 21 / 3.01% 127 / 1.58% 6.92E-03 1.86E-02
Membrane and intracellular structural molecules 9 / 1.29% 35 / 0.44% 7.08E-03 1.87E-02
Other replication, recombination and repair proteins 9 / 1.29% 38 / 0.47% 1.10E-02 2.86E-02
Tight junction 20 / 2.87% 128 / 1.59% 1.39E-02 3.56E-02
Dentatorubropallidoluysian atrophy (DRPLA) 5 / 0.72% 14 / 0.17% 1.46E-02 3.68E-02
Hedgehog signaling pathway 11 / 1.58% 57 / 0.71% 1.82E-02 4.52E-02

Query Genes


Focal adhesion PDGFRB;  PDPK1;  CCND1;  COL11A1;  COL11A2;  BCL2;  BAD;  PIK3CG;  PIK3R1;  PDGFB;  BIRC3;  PIK3CA;  PDGFRA;  ACTB;  MAP2K1;  MAPK9;  SHC1;  FN1;  PTK2;  ITGA2;  ITGB1;  ITGA2B;  FLT1;  CAV1;  AKT1;  VWF;  GRB2;  ITGB3;  ITGB4;  KDR;  IGF1;  JUN;  XIAP;  COL6A1;  PTEN;  LAMA1;  VASP;  COL1A2;  HGF;  COMP;  IGF1R;  MAPK3;  GSK3B;  CDC42;  THBS1;  COL1A1;  EGFR;  RAF1;  EGF;  ACTG1;  ITGAV;  CTNNB1;  SRC;  BRAF;  MET;  PRKCA;  COL4A2;  COL4A4;  COL3A1;  COL2A1;  PRKCB1;  COL4A1;  FLNA;  FLNB;  SOS1;  COL5A1;  COL4A6;  MAPK8;  SPP1;  PXN;  VEGFC;  COL5A3;  VEGFA;  VTN;  HRAS;  RAC1;  ERBB2;  FLNC;  FYN;  MAPK1;  
Prostate cancer PDGFRB;  FRAP1;  PDPK1;  CCND1;  CHUK;  BCL2;  BAD;  PIK3CG;  PIK3R1;  PDGFB;  PIK3CA;  PDGFRA;  HSP90AA1;  MAP2K1;  HSP90AB1;  RELA;  FOXO1;  PTEN;  IKBKB;  GRB2;  TP53;  IGF1;  RB1;  EP300;  FGFR2;  FGFR1;  CDK2;  IKBKG;  AKT1;  LEF1;  IGF1R;  GSK3B;  MDM2;  BRAF;  EGFR;  RAF1;  INS;  AR;  E2F1;  CTNNB1;  NFKB1;  NFKB2;  NFKBIA;  MAPK1;  CDKN1B;  CDKN1A;  MAPK3;  CASP9;  SOS1;  KLK3;  KRAS;  HRAS;  CREBBP;  ERBB2;  EGF;  
Small cell lung cancer CCND1;  CHUK;  BCL2;  BCL2L1;  LAMA1;  PIK3R1;  XIAP;  BIRC3;  PIK3CA;  PTK2;  ITGA2;  ITGA2B;  NOS3;  PTEN;  IKBKB;  TP53;  RB1;  CDK4;  CDKN2B;  CDK2;  PIK3CG;  PIAS3;  NOS2A;  IKBKG;  AKT1;  ITGB1;  PIAS1;  MYC;  E2F1;  NFKB1;  NFKB2;  NFKBIA;  FN1;  COL4A2;  COL4A4;  CASP9;  COL4A1;  SKP2;  FHIT;  COL4A6;  ITGAV;  RXRA;  TRAF5;  TRAF6;  PIAS4;  RELA;  TRAF1;  TRAF2;  TRAF3;  
Chronic myeloid leukemia SMAD4;  CCND1;  CHUK;  BAD;  PIK3CG;  PIK3R1;  PIK3CA;  MAP2K1;  HDAC2;  HDAC1;  ABL1;  IKBKB;  GRB2;  TP53;  SHC1;  RB1;  PTPN11;  BCL2L1;  CDK4;  IKBKG;  AKT1;  BCR;  MDM2;  BRAF;  RAF1;  GAB2;  MYC;  E2F1;  NFKB1;  NFKB2;  NFKBIA;  CDKN1A;  MAPK3;  MAPK1;  RUNX1;  SOS1;  CDKN2A;  CBL;  KRAS;  HRAS;  TGFB2;  RELA;  TGFB1;  
MAPK signaling pathway NFKB1;  MAP3K8;  CHUK;  MAPK8;  PDGFB;  FGF2;  PDGFRA;  MAP2K1;  NF1;  MAPK9;  NGF;  GSTM5;  JUN;  GSTM3;  GSTM2;  TNFRSF1A;  HSPA1A;  TP53;  GSTM1;  CASP3;  IL1A;  IKBKB;  FASLG;  DAXX;  HSPB1;  PRKACA;  NFKB2;  FGF1;  RASA1;  FLNA;  FGFR1;  GSTT2;  MAP3K7IP2;  MAP3K3;  IKBKG;  MAP3K5;  GSTA1;  STK4;  RPS6KA5;  CDC42;  BRAF;  HRAS;  PTPN7;  MAP3K7;  RAF1;  EGF;  TGFB2;  GSTZ1;  IL1B;  TNF;  HSPA8;  GSTP1;  FGF10;  GSTT1;  MAPK1;  AKT1;  MAPK3;  GADD45A;  FGF9;  MAPK14;  FLNC;  PRKCB1;  PRKCA;  DUSP1;  FLNB;  SOS1;  GRB2;  GSTO2;  TRAF6;  FAS;  EGFR;  KRAS;  MAPK7;  FOS;  ATF2;  RAC1;  MYC;  FGF7;  TRAF2;  TGFB1;  
Pancreatic cancer SMAD4;  CCND1;  CHUK;  SMAD3;  BAD;  PIK3CG;  PIK3R1;  PIK3CA;  MAP2K1;  MAPK9;  RAD51;  IKBKB;  TP53;  RB1;  CDK4;  BCL2L1;  IKBKG;  AKT1;  BRCA2;  CDC42;  BRAF;  EGFR;  RAF1;  EGF;  TGFB2;  E2F1;  NFKB1;  NFKB2;  CASP9;  RAC1;  MAPK3;  MAPK1;  MAPK8;  CDKN2A;  VEGFC;  KRAS;  VEGFA;  RELA;  ERBB2;  TGFB1;  
p53 signaling pathway LRDD;  CCND1;  RRM2B;  CDC2;  BBC3;  CHEK2;  GTSE1;  SERPINE1;  CHEK1;  PTEN;  CASP3;  TP53;  BID;  IGF1;  PPM1D;  CDK4;  ATR;  RRM2;  CDK2;  TP53I3;  CCNB1;  SFN;  BAX;  MDM4;  MDM2;  IGFBP3;  RCHY1;  DDB2;  GADD45A;  CDKN1A;  PMAIP1;  CASP9;  CASP8;  TP73;  CDKN2A;  SERPINB5;  ATM;  FAS;  
Colorectal cancer PDGFRB;  CCND1;  BCL2;  SMAD3;  BAD;  PIK3CG;  PIK3R1;  PIK3CA;  PDGFRA;  MAP2K1;  MSH2;  MAPK9;  JUN;  LEF1;  CASP3;  GRB2;  TP53;  APC;  SMAD4;  AKT1;  BAX;  IGF1R;  GSK3B;  BRAF;  EGFR;  RAF1;  TGFB1;  MYC;  CTNNB1;  MSH6;  BIRC5;  MET;  MAPK1;  MAPK3;  CASP9;  MAPK8;  SOS1;  MLH1;  KRAS;  FOS;  TGFB2;  RAC1;  
Apoptosis CHUK;  BID;  BCL2;  BAD;  PIK3CG;  PIK3R1;  TNFSF10;  BIRC3;  PIK3CA;  IRAK1;  TNFRSF1A;  NGF;  CASP3;  IL1A;  IKBKB;  TP53;  NFKB1;  PRKACA;  CASP6;  NFKB2;  BCL2L1;  RIPK1;  IKBKG;  AIFM1;  AKT1;  BAX;  XIAP;  IL1B;  TNF;  TNFRSF10C;  TNFRSF10B;  NFKBIA;  TNFRSF10A;  CASP9;  CASP8;  CSF2RB;  ATM;  FASLG;  FAS;  CFLAR;  RELA;  TRAF2;  
Melanoma PDGFRB;  CCND1;  BAD;  PIK3CG;  PIK3R1;  PDGFB;  PIK3CA;  PDGFRA;  MAP2K1;  PTEN;  MITF;  TP53;  IGF1;  RB1;  CDK4;  FGFR1;  FGF2;  HGF;  AKT1;  IGF1R;  CDH1;  MDM2;  BRAF;  EGFR;  RAF1;  EGF;  E2F1;  MET;  FGF1;  CDKN1A;  MAPK3;  MAPK1;  CDKN2A;  KRAS;  HRAS;  FGF10;  FGF9;  FGF7;  
Non-small cell lung cancer PDPK1;  CCND1;  BAD;  PIK3CG;  PIK3R1;  PIK3CA;  MAP2K1;  PLCG1;  PLCG2;  GRB2;  TP53;  FHIT;  RB1;  CDK4;  RASSF1;  AKT1;  BRAF;  EGFR;  RAF1;  EGF;  E2F1;  MAPK1;  MAPK3;  CASP9;  PRKCB1;  PRKCA;  SOS1;  CDKN2A;  STK4;  KRAS;  HRAS;  ERBB2;  RXRA;  
Toll-like receptor signaling pathway IL12B;  MAP3K8;  CHUK;  PIK3CG;  PIK3R1;  PIK3CA;  MAP2K1;  MAPK9;  JUN;  IRAK1;  TIRAP;  CD40;  IFNB1;  IKBKB;  IFNAR2;  IKBKE;  IL8;  TLR3;  TLR4;  RIPK1;  MAP3K7IP2;  IKBKG;  IRF3;  AKT1;  TLR2;  TICAM1;  MAP3K7;  IL1B;  TNF;  NFKB1;  NFKB2;  NFKBIA;  MAPK3;  RELA;  MAPK14;  MAPK1;  CASP8;  MAPK8;  IL6;  TRAF6;  FOS;  RAC1;  SPP1;  TRAF3;  
Glioma PDGFRB;  FRAP1;  CCND1;  SHC1;  PIK3CG;  PIK3R1;  PDGFB;  PIK3CA;  PDGFRA;  MAP2K1;  PLCG1;  PLCG2;  PTEN;  GRB2;  TP53;  IGF1;  RB1;  CDK4;  AKT1;  IGF1R;  MDM2;  BRAF;  EGFR;  RAF1;  EGF;  E2F1;  CDKN1A;  MAPK3;  MAPK1;  PRKCB1;  PRKCA;  SOS1;  CDKN2A;  KRAS;  HRAS;  
Bladder cancer CCND1;  MAP2K1;  TP53;  IL8;  RB1;  CDK4;  FGFR3;  MMP1;  MMP2;  RASSF1;  MMP9;  CDH1;  MDM2;  BRAF;  EGFR;  HRAS;  EGF;  MYC;  E2F1;  CDKN1A;  MAPK3;  MAPK1;  CDKN2A;  VEGFC;  KRAS;  VEGFA;  RAF1;  ERBB2;  
T cell receptor signaling pathway MAP3K8;  CHUK;  PIK3CG;  PIK3R1;  PIK3CA;  NFKBIE;  CD40LG;  IKBKB;  GRB2;  MALT1;  IFNG;  IL2;  CDK4;  IKBKG;  AKT1;  CDC42;  LCK;  HRAS;  CD4;  CTLA4;  NFATC1;  NFATC2;  ITK;  JUN;  TNF;  CARD11;  NFKB1;  NFKB2;  PTPN6;  TEC;  IL5;  IL4;  SOS1;  CBL;  KRAS;  BCL10;  NFKBIA;  FOS;  FYN;  
Natural killer cell mediated cytotoxicity SYK;  PIK3CG;  PIK3R1;  TNFSF10;  PIK3CA;  MAP2K1;  FCGR3B;  PLCG1;  PLCG2;  GRB2;  CASP3;  ICAM1;  IFNAR2;  HLA-A;  SH2D1A;  HLA-C;  PTPN11;  FCER1G;  MICB;  MICA;  BID;  LCK;  HRAS;  FCGR3A;  RAF1;  NFATC2;  PTK2B;  IFNB1;  TNF;  BRAF;  TNFRSF10C;  TNFRSF10B;  PTPN6;  TNFRSF10A;  ITGB2;  MAPK3;  MAPK1;  PRKCB1;  PRKCA;  SOS1;  SHC1;  HLA-B;  FASLG;  FAS;  KRAS;  NFATC1;  RAC1;  IFNG;  FYN;  
Protein kinases JAK2;  PDPK1;  CHUK;  PLK3;  JAK3;  BMX;  HIPK2;  PTK2;  IRAK1;  TAF1;  FLT3;  FLT1;  IKBKB;  BTK;  MET;  KDR;  ATR;  FER;  FES;  JAK1;  IGF1R;  IGF2R;  VRK1;  LCK;  SGK1;  EGFR;  TP53RK;  FGFR2;  SRC;  INSR;  SGK2;  PRKDC;  STK11;  FGFR3;  MAPK3;  MAPK1;  AURKA;  MAPK8;  MAPK7;  ERBB2;  PDGFRB;  FRAP1;  MAP3K8;  SYK;  CDC2;  PDGFRA;  CHEK2;  MAPK9;  STK4;  PRKACA;  KIT;  LMTK2;  CDK4;  RIPK1;  FGFR1;  CDK2;  FGFR4;  MAP3K3;  IKBKG;  MAP3K5;  ABL1;  RPS6KA5;  GSK3B;  NEK6;  IKBKE;  MAPK14;  EPHA4;  PRKCB1;  PRKCA;  PRKCE;  RET;  BRAF;  PRKCD;  LYN;  SGK3;  TYK2;  MAP3K7;  RAF1;  PTK2B;  TEC;  CDK9;  PLK1;  CDK5;  MAP2K1;  CSNK2A1;  CSNK1A1;  CSNK1D;  ALK;  EPHA2;  CHEK1;  AKT1;  BCR;  ITK;  HCK;  ATM;  FYN;  
Endometrial cancer PDPK1;  CCND1;  BAD;  PIK3CG;  PIK3R1;  PIK3CA;  MAP2K1;  LEF1;  PTEN;  GRB2;  TP53;  APC;  AKT1;  GSK3B;  CDH1;  BRAF;  EGFR;  RAF1;  EGF;  MYC;  CTNNB1;  MAPK1;  MAPK3;  CASP9;  SOS1;  MLH1;  KRAS;  HRAS;  ERBB2;  
Cytokine-cytokine receptor interaction IL12B;  PDGFRB;  IL6;  IL13;  IL12RB1;  CCL15;  TNFSF11;  PDGFB;  PDGFRA;  CXCR4;  CXCL12;  TNFRSF1B;  TNFRSF1A;  TSLP;  TNF;  CD40LG;  CD40;  FLT1;  IFNB1;  IL1A;  CCL2;  IFNAR2;  MET;  IFNG;  KIT;  KDR;  LTA;  IL2;  IL6R;  BMP7;  GH1;  BMP2;  LIF;  BMP4;  TGFB1;  HGF;  IL6ST;  IL18;  IL17A;  FLT3;  LEPR;  TNFSF10;  LEP;  OSM;  PRL;  TNFRSF11B;  EGFR;  EGF;  TGFB2;  IL1B;  TNFRSF11A;  TNFRSF10C;  TNFRSF10B;  TNFRSF10A;  PRLR;  CCL5;  IL5;  IL4;  IL8;  EPO;  TNFRSF8;  CSF2RB;  FASLG;  FAS;  VEGFC;  VEGFA;  GHR;  
Acute myeloid leukemia FRAP1;  CCND1;  CHUK;  BAD;  PIK3CG;  PIK3R1;  PIK3CA;  MAP2K1;  LEF1;  IKBKB;  GRB2;  PML;  RARA;  IKBKG;  AKT1;  KIT;  BRAF;  RAF1;  FLT3;  MYC;  NFKB1;  NFKB2;  MAPK3;  MAPK1;  RUNX1;  SOS1;  KRAS;  HRAS;  RELA;  
ErbB signaling pathway FRAP1;  BAD;  PIK3CG;  PIK3R1;  PIK3CA;  MAP2K1;  PLCG1;  PTK2;  ABL1;  GRB2;  GAB1;  PLCG2;  AKT1;  GSK3B;  BRAF;  HRAS;  EGFR;  RAF1;  EGF;  MYC;  JUN;  SRC;  CDKN1A;  MAPK3;  MAPK1;  PRKCB1;  PRKCA;  MAPK8;  SOS1;  SHC1;  CBL;  KRAS;  MAPK9;  ERBB2;  AREG;  
Jak-STAT signaling pathway JAK2;  STAT5B;  CCND1;  BCL2L1;  PIK3CG;  PIK3R1;  JAK3;  PIK3CA;  JAK1;  STAT1;  SPRY2;  GRB2;  EP300;  SOCS1;  PIAS3;  AKT1;  TYK2;  PIAS1;  MYC;  SOCS3;  STAT6;  STAT3;  STAT4;  STAT5A;  SOS1;  CBL;  PIAS4;  CREBBP;  
Cell cycle SMAD4;  CCNA2;  PCNA;  SMAD3;  CDC2;  CHEK2;  HDAC2;  HDAC1;  CCND1;  ABL1;  TP53;  CHEK1;  RB1;  EP300;  CDK4;  ATR;  CDKN2B;  CDK2;  CCNA1;  CDC25C;  CCNB1;  SFN;  GSK3B;  GADD45A;  MDM2;  PLK1;  CDC14A;  TGFB1;  TGFB2;  E2F1;  PTTG1;  PRKDC;  CDKN1B;  CDKN1A;  SKP2;  CDKN2A;  ATM;  RBL2;  CREBBP;  
Cellular antigens PECAM1;  FLT3;  HLA-DRA;  HLA-DRB1;  KDR;  HLA-DRB5;  HLA-DRB3;  TNFRSF11B;  F3;  IGF1R;  IGF2R;  CDH1;  CTLA4;  LRP1;  INSR;  THBD;  CD4;  PDGFRB;  TNFSF11;  PDGFRA;  ITGA2;  TNFRSF1B;  TNFRSF1A;  ITGA2B;  ICAM1;  IL6R;  IL6ST;  FGFR2;  FGFR1;  FGFR3;  FGFR4;  KIT;  LEPR;  PROCR;  SIRPA;  ABCB1;  SLAMF1;  GP1BA;  IL12RB1;  HLA-DRB4;  TNFSF10;  CXCR4;  KEL;  TLR2;  CD74;  ACE;  ITGB3;  ITGB4;  SH2D1A;  TLR3;  TLR4;  VCAM1;  CEACAM1;  MICA;  TBX21;  MAPK14;  FCGR2A;  ITGB2;  ITGB1;  CD44;  HLA-DQB1;  FCGR3B;  FCGR3A;  ITGAV;  MET;  CD84;  LAIR1;  ALK;  MICB;  CSF2RB;  CD40LG;  CD40;  HLA-DMA;  HLA-DMB;  HLA-A;  HLA-B;  HLA-C;  TNFRSF11A;  TNFRSF10C;  TNFRSF10B;  TNFRSF10A;  CD36;  HLA-DQA1;  HLA-DPB1;  HLA-DPA1;  TNFRSF8;  FASLG;  FAS;  NOD2;  NOTCH1;  
Type I diabetes mellitus IL12B;  INS;  HLA-DRB5;  IL2;  IL1B;  IL1A;  HLA-DRA;  HLA-DRB1;  HLA-B;  HLA-C;  HLA-DRB4;  LTA;  HLA-DRB3;  HLA-DMA;  TNF;  HLA-DMB;  HLA-DQB1;  HLA-DQA1;  HLA-DPB1;  HLA-DPA1;  FASLG;  FAS;  HLA-A;  IFNG;  
Adipocytokine signaling pathway FRAP1;  JAK1;  CHUK;  JAK2;  MAPK9;  TNFRSF1B;  TNFRSF1A;  IKBKB;  NFKB1;  PTPN11;  IKBKG;  IRS1;  AKT1;  TYK2;  LEPR;  LEP;  JAK3;  NFKBIE;  TNF;  SOCS3;  NFKB2;  NFKBIA;  STK11;  CD36;  MAPK8;  IRS2;  RELA;  RXRA;  TRAF2;  
Fc epsilon RI signaling pathway IL13;  PIK3CG;  PIK3R1;  PIK3CA;  MAP2K1;  MAPK9;  PLCG2;  SYK;  LYN;  BTK;  FCER1G;  INPP5D;  AKT1;  HRAS;  RAF1;  GAB2;  MAPK3;  TNF;  IL5;  MAPK14;  MAPK1;  IL4;  MAPK8;  SOS1;  GRB2;  KRAS;  PLCG1;  RAC1;  FYN;  
Renal cell carcinoma PIK3CG;  PIK3R1;  PIK3CA;  MAP2K1;  GRB2;  GAB1;  VEGFC;  EP300;  PTPN11;  HGF;  AKT1;  CDC42;  BRAF;  RAF1;  TGFB1;  TGFB2;  JUN;  MET;  RAC1;  MAPK3;  MAPK1;  SOS1;  HIF1A;  KRAS;  VEGFA;  HRAS;  CREBBP;  VHL;  
B cell receptor signaling pathway SYK;  PIK3CG;  INPP5D;  PIK3CA;  CHUK;  LYN;  IKBKB;  BTK;  MALT1;  PTPN6;  BLNK;  IKBKG;  PIK3R1;  AKT1;  GSK3B;  CARD11;  NFATC1;  NFATC2;  FOS;  NFKBIE;  JUN;  NFKB1;  NFKB2;  NFKBIA;  KRAS;  BCL10;  HRAS;  RAC1;  
ECM-receptor interaction COL11A1;  COL11A2;  LAMA1;  ITGA2;  ITGA2B;  VWF;  ITGB3;  ITGB4;  THBS1;  COL6A1;  COL1A2;  GP1BA;  COMP;  COL1A1;  ITGB1;  GP6;  COL3A1;  FN1;  COL4A2;  COL4A4;  CD44;  COL2A1;  CD36;  COL4A1;  VTN;  COL5A1;  COL4A6;  ITGAV;  COL5A3;  SPP1;  
CAM ligands COL11A1;  COL11A2;  LAMA1;  PDGFB;  VWF;  THBS1;  FGB;  FGF1;  COL6A1;  FGG;  F10;  HGF;  COL1A2;  MMP1;  MMP2;  COMP;  LCK;  FGF2;  TGFB1;  TGFB2;  PLG;  COL1A1;  FN1;  COL4A2;  COL4A4;  COL3A1;  COL2A1;  COL4A1;  VTN;  COL5A1;  COL4A6;  SPP1;  F2;  VEGFC;  COL5A3;  VEGFA;  FGF10;  FGF9;  FGF7;  FYN;  F13A1;  
VEGF signaling pathway BAD;  PIK3CG;  PIK3R1;  PIK3CA;  MAP2K1;  PLCG1;  PTK2;  PXN;  KDR;  PLCG2;  AKT1;  CDC42;  HRAS;  RAF1;  NFATC2;  MAPK14;  SRC;  HSPB1;  MAPK1;  MAPK3;  CASP9;  PRKCB1;  PRKCA;  KRAS;  NFATC1;  RAC1;  
Regulation of actin cytoskeleton PDGFRB;  PIK3CG;  PIK3R1;  PDGFB;  PIK3CA;  PDGFRA;  ACTB;  MSN;  PTK2;  ITGA2;  ITGA2B;  WAS;  ITGB3;  ITGB4;  FGF1;  IQGAP1;  APC;  FGFR2;  RDX;  FGFR3;  FGFR4;  GSN;  ITGB1;  CDC42;  BRAF;  FGF2;  EGFR;  RAF1;  INS;  ACTG1;  FGFR1;  FN1;  ITGB2;  FGF9;  MAPK3;  MAPK1;  MAP2K1;  TMSB4X;  SOS1;  ITGAV;  F2;  PXN;  KRAS;  HRAS;  FGF10;  RAC1;  FGF7;  F2R;  EGF;  
Cytokines IL12B;  IL13;  TNFSF11;  PDGFB;  IGF1;  CXCL12;  MSTN;  TSLP;  FGF7;  IL1RN;  NGF;  IFNB1;  IL1A;  CCL2;  EPO;  IFNG;  IL8;  LTA;  IL2;  BMP7;  BMP4;  BMP2;  LIF;  GH1;  FGF1;  FGF2;  GDNF;  HGF;  CD40LG;  IL18;  IL17A;  TNFSF10;  LEP;  OSM;  EGF;  TGFB2;  IL1B;  TNF;  CCL5;  IL5;  IL4;  IL6;  PRL;  CCL15;  FASLG;  VEGFC;  VEGFA;  FGF10;  FGF9;  GDF15;  TGFB1;  
Epithelial cell signaling in Helicobacter pylori infection CHUK;  RAC1;  MAPK9;  PLCG2;  CASP3;  LYN;  IKBKB;  NFKB1;  ATP6V1B1;  PTPN11;  ATP6V1E1;  IKBKG;  CDC42;  NOD1;  EGFR;  JUN;  SRC;  MET;  NFKB2;  NFKBIA;  TJP1;  MAPK14;  MAPK8;  PLCG1;  RELA;  
Adherens junction SMAD3;  SMAD4;  ACTB;  RAC1;  LEF1;  WAS;  MET;  EP300;  MAP3K7;  IGF1R;  CDH1;  CDC42;  EGFR;  ACTG1;  CTNNB1;  SRC;  INSR;  FGFR1;  PTPN6;  TJP1;  MAPK3;  MAPK1;  CSNK2A1;  CREBBP;  ERBB2;  FYN;  
Leukocyte transendothelial migration PLCG2;  ACTG1;  PECAM1;  GNAI1;  PIK3CG;  PIK3R1;  PIK3CA;  ACTB;  MSN;  CXCL12;  PLCG1;  PTK2;  ICAM1;  PXN;  VCAM1;  PTPN11;  NCF1;  MMP2;  MMP9;  CDC42;  PTK2B;  ITK;  CTNNB1;  CXCR4;  ITGB2;  ITGB1;  MAPK14;  PRKCB1;  PRKCA;  VASP;  RAC1;  
Thyroid Cancer LEF1;  CCND1;  MAPK3;  MAPK1;  TP53;  CDH1;  BRAF;  HRAS;  MAP2K1;  RET;  KRAS;  PPARG;  MYC;  CTNNB1;  RXRA;  
Gap junction GNAS;  PDGFRB;  GNAI1;  CDC2;  PDGFB;  PDGFRA;  MAP2K1;  DRD2;  PRKACA;  EGFR;  RAF1;  EGF;  SRC;  MAPK1;  TJP1;  MAPK3;  TUBA4A;  PRKCB1;  PRKCA;  MAPK7;  TUBA3C;  SOS1;  GRB2;  KRAS;  CSNK1D;  GJA1;  HRAS;  
Antigen processing and presentation LTA;  HSP90AA1;  TAP1;  HSP90AB1;  HSPA1A;  NFYA;  HLA-DMA;  CD74;  HLA-DRA;  HLA-DRB1;  HLA-B;  HLA-C;  HLA-DRB4;  HLA-DRB5;  HLA-DRB3;  RFX5;  HSPA8;  HLA-DMB;  TAP2;  HLA-DQB1;  HLA-DQA1;  HLA-DPB1;  HLA-DPA1;  HLA-A;  CD4;  
Progesterone-mediated oocyte maturation CCNA2;  GNAI1;  CDC2;  PIK3CG;  PIK3R1;  PIK3CA;  HSP90AA1;  MAP2K1;  MAPK9;  HSP90AB1;  PRKACA;  IGF1;  CDK2;  CCNA1;  CDC25C;  CCNB1;  AKT1;  IGF1R;  BRAF;  RAF1;  INS;  MAPK14;  PLK1;  MAPK3;  MAPK1;  MAPK8;  KRAS;  
Insulin signaling pathway FRAP1;  PDPK1;  BAD;  PIK3CG;  PIK3R1;  PIK3CA;  MAP2K1;  MAPK9;  FOXO1;  IKBKB;  GRB2;  SOCS3;  PRKACA;  SOCS1;  IRS1;  INPP5D;  AKT1;  GSK3B;  BRAF;  RAF1;  INS;  INSR;  MAPK3;  MAPK1;  MAPK8;  SOS1;  SHC1;  CBL;  IRS2;  KRAS;  HRAS;  
TGF-beta signaling pathway SMAD1;  NOG;  SMAD4;  TGFB2;  SP1;  DCN;  IFNG;  THBS1;  SMAD3;  BMP7;  BMP4;  BMP2;  EP300;  CDKN2B;  COMP;  TGFB1;  MYC;  TNF;  PPP2CA;  PITX2;  MAPK3;  MAPK1;  RBL2;  CREBBP;  
Type II diabetes mellitus FRAP1;  MAPK3;  MAPK1;  IKBKB;  MAPK8;  SOCS3;  PIK3CG;  PIK3R1;  IRS1;  PIK3CA;  IRS2;  MAPK9;  INS;  SOCS1;  TNF;  INSR;  
Huntington's disease CLTC;  CBS;  CASP3;  CASP8;  CASP1;  NCOR1;  TP53;  CASP6;  GRB2;  EP300;  RASA1;  HTT;  CREBBP;  
Melanogenesis GNAS;  GNAI1;  MAP2K1;  EDNRB;  LEF1;  MITF;  DCT;  PRKACA;  EP300;  CTNNB1;  WNT2;  KIT;  TYR;  GSK3B;  RAF1;  TYRP1;  MAPK1;  MAPK3;  MC1R;  PRKCB1;  PRKCA;  KRAS;  HRAS;  CREBBP;  
Complement and coagulation cascades PLG;  VWF;  PLAT;  PROS1;  PROC;  THBD;  SERPIND1;  F2;  F7;  F8;  F2R;  F3;  F5;  SERPINE1;  FGB;  FGG;  F10;  PLAU;  F13A1;  
Metabolism of xenobiotics by cytochrome P450 CYP1A2;  EPHX1;  CYP1A1;  GSTA1;  CYP2C9;  CYP3A5;  UGT1A1;  GSTO2;  GSTZ1;  CYP1B1;  GSTM5;  GSTM3;  GSTM2;  CYP2E1;  GSTM1;  GSTP1;  CYP3A4;  GSTT1;  GSTT2;  
Cell adhesion molecules (CAMs) PDGFRB;  PECAM1;  PDGFRA;  ACAN;  ITGA2;  MPZL1;  ITGA2B;  CD40LG;  CD40;  HLA-DMA;  ICAM1;  HLA-DRA;  HLA-DRB1;  HLA-B;  HLA-C;  HLA-DRB4;  HLA-DRB5;  HLA-DRB3;  VCAM1;  FGFR2;  FGFR1;  FGFR3;  FGFR4;  CEACAM1;  CDH1;  HLA-A;  CTLA4;  CDH23;  MPZ;  HLA-DMB;  ITGB2;  ITGB1;  CD44;  HLA-DQB1;  HLA-DQA1;  HLA-DPB1;  HLA-DPA1;  ITGAV;  ITGB3;  ITGB4;  CD4;  CD84;  
mTOR signaling pathway FRAP1;  PDPK1;  MAPK3;  MAPK1;  AKT1;  PIK3CG;  PIK3R1;  STK11;  PIK3CA;  IGF1;  HIF1A;  VEGFA;  INS;  VEGFC;  BRAF;  
Dorso-ventral axis formation MAPK3;  MAPK1;  GRB2;  SOS1;  MAP2K1;  EGFR;  KRAS;  ETS1;  ETS2;  NOTCH1;  
GnRH signaling pathway GNAS;  MAP3K3;  MMP2;  MAPK14;  MAPK1;  GRB2;  MAPK8;  MAPK7;  PRKACA;  SOS1;  CDC42;  HRAS;  MAP2K1;  MAPK9;  MAPK3;  RAF1;  PTK2B;  JUN;  KRAS;  SRC;  EGFR;  
Ubiquitin mediated proteolysis NEDD4L;  STUB1;  ERCC8;  XIAP;  BIRC3;  BTRC;  PML;  UBE2I;  SOCS1;  PIAS3;  CUL5;  MDM2;  BRCA1;  CUL7;  PIAS1;  SOCS3;  UBE3A;  RCHY1;  NEDD4;  DDB2;  SKP2;  CBL;  TRAF6;  PIAS4;  VHL;  
Wnt signaling pathway CCND1;  SMAD3;  SMAD4;  MAPK9;  JUN;  LEF1;  BTRC;  TP53;  PRKACA;  EP300;  APC;  WNT2;  MMP7;  GSK3B;  MAP3K7;  NFATC1;  NFATC2;  MYC;  CTNNB1;  PPP2CA;  RAC1;  PRKCB1;  PRKCA;  MAPK8;  CSNK2A1;  CSNK1A1;  CREBBP;  
Long-term depression GNAS;  MAPK3;  LYN;  PRKCB1;  PRKCA;  GNAI1;  IGF1R;  IGF1;  BRAF;  HRAS;  MAP2K1;  RAF1;  KRAS;  NOS3;  NOS2A;  PPP2CA;  MAPK1;  
Glutathione metabolism GPX1;  GSTA1;  GSTO2;  GSTZ1;  GSTM5;  GSTM3;  GSTM2;  GSTM1;  GSTP1;  GSTT1;  GSTT2;  
Hematopoietic cell lineage FLT3;  IL1B;  IL1A;  CD36;  EPO;  ITGB3;  IL6;  IL6R;  KIT;  IL4;  CD4;  ITGA2;  GP1BA;  CD44;  TNF;  ITGA2B;  IL5;  
Long-term potentiation GRIN2A;  GRIN1;  MAPK3;  MAPK1;  PRKCB1;  GRIN2B;  PRKACA;  PRKCA;  BRAF;  HRAS;  MAP2K1;  RAF1;  KRAS;  CREBBP;  EP300;  
Amyotrophic lateral sclerosis (ALS) CAT;  BCL2;  TP53;  BAD;  BAX;  BCL2L1;  
One carbon pool by folate MTHFR;  TYMS;  SHMT1;  MTHFD1;  MTR;  ATIC;  
Axon guidance ABL1;  EPHA4;  MAPK3;  CDK5;  NFATC2;  GNAI1;  FES;  GSK3B;  CDC42;  CXCR4;  HRAS;  ITGB1;  NFATC1;  RASA1;  MAPK1;  PTK2;  KRAS;  RAC1;  MET;  FYN;  EPHA2;  
Membrane and intracellular structural molecules GJB1;  GJB4;  GJB2;  GJA4;  GJC1;  GJA3;  GJA5;  GJB6;  GJB3;  
Other replication, recombination and repair proteins RAD51;  PCNA;  RPA1;  MGMT;  DNMT1;  BLM;  OGG1;  APEX1;  TERT;  
Tight junction AKT1;  PTEN;  TJP1;  PRKCD;  PRKCB1;  PRKCA;  GNAI1;  PRKCE;  CDC42;  HRAS;  ACTB;  CSNK2A1;  KRAS;  CDK4;  ACTG1;  MYH9;  MYH10;  CTNNB1;  SRC;  PPP2CA;  
Dentatorubropallidoluysian atrophy (DRPLA) INSR;  INS;  CASP3;  CASP1;  CASP8;  
Hedgehog signaling pathway BTRC;  CSNK1A1;  PRKACA;  LRP2;  GSK3B;  PTCH1;  BMP7;  BMP4;  BMP2;  CSNK1D;  WNT2;  

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