SADR Gengle™ - a Database Inheriting Google® Technology in Presenting Genes Responsible for Serious Adverse Drug Reactions

Torsades de Points



Pathway Foreground Gene Count & Ratio Background Gene Count & Ratio p-value q-value
Receptors and channels 12 / 63.16% 1260 / 15.69% 3.92E-06 None
Long-term potentiation 3 / 15.79% 69 / 0.86% 6.00E-04 None
Calcium signaling pathway 4 / 21.05% 171 / 2.13% 6.48E-04 None
GnRH signaling pathway 3 / 15.79% 94 / 1.17% 1.43E-03 None
Olfactory transduction 2 / 10.53% 28 / 0.35% 2.21E-03 None
Taste transduction 2 / 10.53% 50 / 0.62% 6.52E-03 None
Phosphatidylinositol signaling system 2 / 10.53% 75 / 0.93% 1.39E-02 None
Gap junction 2 / 10.53% 98 / 1.22% 2.28E-02 None
Melanogenesis 2 / 10.53% 101 / 1.26% 2.41E-02 None
Insulin signaling pathway 2 / 10.53% 132 / 1.64% 3.91E-02 None

Query Genes


Receptors and channels KCNQ3;  ITPR3;  KCNQ1;  KCNQ2;  KCNH7;  KCNE1;  KCNH2;  SCN2A;  SCN5A;  KCNE4;  KCNE2;  KCNE1L;  
Long-term potentiation CALM1;  ITPR3;  PRKACA;  
Calcium signaling pathway SLC8A1;  CALM1;  ITPR3;  PRKACA;  
GnRH signaling pathway CALM1;  ITPR3;  PRKACA;  
Olfactory transduction CALM1;  PRKACA;  
Taste transduction PRKACA;  ITPR3;  
Phosphatidylinositol signaling system CALM1;  ITPR3;  
Gap junction PRKACA;  ITPR3;  
Melanogenesis CALM1;  PRKACA;  
Insulin signaling pathway CALM1;  PRKACA;  

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